SIMAGIS® SRID™. Fully automated analysis of immunoglobulin concentration of using Manchini method (Single Radial Immunodiffusion)

SIMAGIS® SRID™ allows specialists to obtain objective quantitative data on immunoglobulin concentrations while diagnosing diseases and determining the immune status.

The product employs a simple and reliable method of estimating the concentration of immunoglobulines IgA, IgG, IgM in the serum and the biological liquids – Single Radial Immunodiffusion (SRID), using Manchini method.

The method is based on precipitation of the products from reacting with its specific antibodies in a thin agarose layer. The precipitin ring diameter is proportional to the logarithm of the immunoglobulin concentration in the tested samples. The measurements of the precipitate diameters are used to determine the actual concentrations based on standardized calibration curve.

SIMAGIS® SRID™ offers an original mathematical algorithm for the determination of the immunoglobulin concentrations via automatic recognition and measurements of precipitin rings in the image of SRD assay slide. It can handle SRD plates of various shape and size, with any number of wells for analysis. The solution allows analysis of images with different quality and contrast.

SIMAGIS® SRID™ Solution includes

	Automatic localization and numbering of wells in the initial image of the SRD assay slide
	Automatic identification of well boundaries
	Automatic diameter measurement of the precipitin rings and identification of empty wells in the image
	Building standardized calibration curve
	Generation of the report with the immunoglobuline concentrations measurement results
	Export of result data to MS Excel